Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 17, Issue 3, Pages 152-157Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0889-1591(02)00098-3
Keywords
interleukin-1; neuronal injury; stroke; receptors; mechanisms; therapeutics
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Interleukin-1 (IL-1) expression in the brain increases in response to acute and chronic insults, and IL-1 contributes directly to experimentally induced ischaemic, excitotoxic, and traumatic brain injury. Release and cleavage of active IL-1beta may be achieved via purinergic P2X7 receptors and activation of caspase-1. The mechanisms of action of IL-1 are largely unknown, but may involve effects on glia, endothelia, and neurones, or on physical parameters within the brain such as temperature or acidity. The naturally occurring IL-1 receptor antagonist (IL-1ra) is currently being considered for treatment of stroke and other disorders. (C) 2003 Elsevier Science (USA). All rights reserved.
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