Journal
NATURE GENETICS
Volume 34, Issue 2, Pages 145-147Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1155
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Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.
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