Journal
AMERICAN JOURNAL OF SURGERY
Volume 185, Issue 6, Pages 544-549Publisher
EXCERPTA MEDICA INC
DOI: 10.1016/S0002-9610(03)00077-1
Keywords
scintimammography; mammography; (99m)Technetium; sestamibi; breast cancer; breast imaging
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Background: The purpose of this study is to evaluate the efficacy of scintimammography with (99m)Technetium-Sestamibi for the diagnosis of breast cancer. Methods: This was a multicenter prospective cohort clinical trial. A total of 1,734 women were enrolled of whom 1,243 had complete data upon study completion. Results: The mean +/- standard error age of the patients is 56 +/- 12 years (with a range of 19 to 94). Mammographic results were classified by the Breast Imaging Reporting and Data System (BIRADS) as 199 (16%) BIRADS 5, 149 (12%) BIRADS 4, 199 (16%) BIRADS 3, and 696 (56%) BIRADS 2 or 1. Scintimammography was positive for 322 (26%) of the patients and negative for 921 (76%). Histopathology showed malignancy for 201 (16%) of the patients. Sensitivity and specificity of scintimammography was estimated 93% and 87% respectively. A positive predictive value (PPV) of 58% with a negative predictive value of 98% were calculated. Conclusions: The present study suggests that scintimammography with (99m)Technetium-Sestamibi is highly accurate for the detection of breast cancer. (C) 2003 Excerpta Medica, Inc. All rights reserved.
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