Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 11, Pages 2125-2135Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00488
Keywords
kinesin; scaffold; signal transduction; motors; cytoskeleton; protein trafficking
Categories
Ask authors/readers for more resources
The human genome has more than 40 kinesin genes whose protein products organize intracellular traffic along microtubules. Research during the past two years has begun to elucidate the cargoes carried by kinesins and the nature of the kinesin-cargo linkage. Modular protein-protein interactions connect kinesins to diverse cellular molecules, which, apart from their other functions, serve as kinesin-cargo linkers. Many of these newly identified linkers are scaffolds for signaling pathways, and mounting evidence now indicates that kinesins transport pre-assembled signaling modules as vesicular cargo. These findings bring together two fields, signal transduction and molecular motors, and lead to a deeper understanding of the interplay between trafficking, localization and intercellular communication.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available