Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 162, Issue 2, Pages 259-268Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1090-7807(03)00117-4
Keywords
C-13; in vivo human brain; glutamate; neuron; spectroscopy processing; glia; Alzheimer; epilepsy; ketogenic diet
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In clinical C-13 infusion studies, broadband excitation of 200 ppm of the human brain yields C-13 MR spectra with a time resolution of 2-5 min and generates up to 2000 metabolite peaks over 2 h. We describe a fast, automated, observer-independent technique for processing {H-1-decoupled} C-13 spectra. Quantified C-13 spectroscopic signals, before and after the administration of [1-C-13]glucose and/or [1-C-13]acetate in human subjects are determined. Stepwise improvements of data processing are illustrated by examples of normal and pathological results. Variation in analysis of individual C-13 resonances ranged between 2 and 14%. Using this method it is possible to reliably identify subtle metabolic effects of brain disease including Alzheimer's disease and epilepsy. (C) 2003 Elsevier Science (USA). All rights reserved.
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