Journal
NATURE MEDICINE
Volume 9, Issue 6, Pages 727-728Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm880
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Funding
- NIAID NIH HHS [AI43222] Funding Source: Medline
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Latent HIV-1 persists in resting memory CD4(+) T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.
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