Journal
MICROBES AND INFECTION
Volume 5, Issue 7, Pages 667-675Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(03)00092-3
Keywords
virulence; fungi; Cryptococcus neoformans; amoebae; environment; ecology; pathogenicity; fungal; virulence factor
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Funding
- NHLBI NIH HHS [HL59842] Funding Source: Medline
- NIAID NIH HHS [AI13342, AI33774] Funding Source: Medline
- NIGMS NIH HHS [T32GM 07491] Funding Source: Medline
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The origin of virulence in environmental fungi that have no requirement for animal hosts in their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with virulence factors for mammalian pathogenesis that also contribute to environmental survival. C. neoformans virulence may originate from selection pressures imposed by environmental predators. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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