Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 31, Issue -, Pages 648-651Publisher
PORTLAND PRESS
DOI: 10.1042/BST0310648
Keywords
bacterial infection; fruit fly; innate immunity; signal transduction
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Funding
- NIAID NIH HHS [1P01 AI44220] Funding Source: Medline
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The Drosophila Toll receptor controls the immune response to Gram-positive bacteria and fungi by activating a signalling pathway partially conserved throughout evolution. The Drosophila genome encodes eight additional Toll-related receptors, most of which appear to carry out developmental rather than immune functions. one exception may be Toll-9, which shares structural and functional similarities with mammalian TLRs.
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