Journal
BIOMEDICAL CHROMATOGRAPHY
Volume 17, Issue 4, Pages 226-230Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/bmc.216
Keywords
(+/-)-atenolol; (+/-)-metoprolol; (+/-)-propranolol; enantiomerc resolution; impregnated TLC; L-aspartic acid
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Resolution of three commonly used beta-blockers, (+/-)-atenolol, (+/-)-metoprolol and (+/-)-propranolol, into their enantiomers has been achieved using normal-phase TLC on silica gel plates impregnated with L-aspartic acid as the chiral selector. Different combinations of acetonitrile-methanol-water as mobile phase were found to be successful in resolving the enantiomers. The spots were detected with iodine and the detection limits were found to be 0.26 mug for atenolol and 0.23 mug for each of metoprolol and propranolol as racemate. Copyright (C) 2003 John Wiley Sons, Ltd.
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