Journal
DEVELOPMENTAL CELL
Volume 4, Issue 6, Pages 775-789Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(03)00162-X
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Funding
- NIGMS NIH HHS [GM57438, GM51219, R01 GM057438, R01 GM057438-03, R01 GM051219-07] Funding Source: Medline
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Nuclear pore complexes (NPCs) are large protein-aceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. This review focuses on the most outstanding issues involving NPC structure, assembly, and function.
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