Journal
NEUROLOGICAL RESEARCH
Volume 25, Issue 4, Pages 351-356Publisher
FOREFRONT PUBL GROUP
DOI: 10.1179/016164103101201670
Keywords
positron emission tomography; progressive dementia; amyotrophic lateral sclerosis; motor neuron disease; cerebral oxygen metabolism; cerebral blood flow
Categories
Ask authors/readers for more resources
We examined regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO(2)) in 70 patients with progressive dementia and amyotrophic lateral sclerosis (DALS), in 21 patients with classical amyotrophic lateral sclerosis without dementia (ALS), and in 17 controls. The mean rCBF and rCMRO(2), especially in the anterior cerebral hemispheres, decreased significantly in patients with DALS. Patients with only ALS showed very mild changes in rCBF and rCMRO(2) which were not significant except for the reductions in the sensorimotor area. Some rCBF and rCMRO(2) values in ALS showed a significant correlation with some neurological signs indicating upper motor neuron involvement. These data suggest that hypoperfusion and oxygen hypometabolism in the anterior cerebral hemispheres have an etiological relationship with the deterioration of intellect in patients with progressive dementia and ALS. The metabolic and perfusional changes in the cerebral cortex of ALS patients are likely to depend on upper motor neuron involvement, but they are not confined to the neurons of the corticospinal tract.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available