Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 11, Pages 6580-6584Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.11.6580-6584.2003
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Funding
- NHLBI NIH HHS [HL-36577, HL-60015, P01 HL036577] Funding Source: Medline
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Respiratory syncytial virus (RSV) infection in the neonate can alter respiratory rates, i.e., lead to episodes of apnea. We show that RSV G glycoprotein reduces respiratory rates associated with the induction of substance P (SP) and G glycoprotein-CX3CR1 interaction, an effect that is inhibited by treatment with anti-G glycoprotein, anti-SP, or anti-CX3CR1 monoclonal antibodies. These, data suggest new approaches for treating some aspects of RSV disease.
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