Journal
VACCINE
Volume 21, Issue -, Pages S35-S37Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00198-1
Keywords
serological memory; plasma cells; antibodies
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In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) poyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relative contribution of antigen induced short- and long-lived plasma cells versus polyclonal activation of all memory B cells. Antigenic boost sustains high levels of serum antibodies only for a few months, while polyclonal activation sustains low levels of protective antibodies for a human lifetime. (C) 2003 Elsevier Science Ltd. All rights reserved.
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