Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 4, Issue 6, Pages 435-445Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1127
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The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability and cell survival. Homologous recombination provides an efficient and faithful pathway of repair, especially in replicating cells, in which it plays a major role in tumour avoidance. Many of the enzymes that are involved in recombination have been isolated, and the details of this pathway are now being unravelled at the molecular level.
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