Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 14, Issue 6, Pages 314-318Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0955-2863(03)00051-2
Keywords
atherosclerosis; Cholestin (Monascus purpureus rice; red yeast rice); HMG-CoA reductase inhibitors; hyperlipidemia; red yeast rice
Funding
- NHLBI NIH HHS [HL00734] Funding Source: Medline
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Long-term effects of Cholestin (Monascus purpureus rice; red yeast rice) on serum lipids and severity of atherosclerosis were examined in rabbits fed for 200 days on a semi-purified diet containing 0.25% cholesterol. Serum total cholesterol was 25 and 40% lower, respectively, in rabbits fed 0.4 or 1.35 g/kg/day of Cholestin (Monascus purpureus rice; red yeast rice) compared to controls. This treatment also lowered serum LDL cholesterol. This 200-day treatment significantly reduced serum triglycerides and atherosclerotic index (ratio of non-HDL-cholesterol to HDL-cholesterol). Although similar reductions of total, LDL-cholesterol and triglycerides were observed, a parallel group of rabbits fed lovastatin (0.0024g/kg/day) failed to reduce the index significantly. Apolipoprotein A, was increased and apolipoprotein B was reduced in all treatment groups. Severity of atherosclerosis was reduced significantly in all treatment groups. The sudanophilic area of involvement was 80.6% in controls, and reduced significantly; to 30.1% on the low dose of Cholestin (Monascus purpureus rice; red yeast rice), and 17.2% on the high dose. Lovastatin reduced severity of lesions by 89% (sudanophilia) and 84% (visual). Visual grading of lesion severity showed reduction by 38% and 68%. (C) 2003 Elsevier Inc. All rights reserved.
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