Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 13, Issue 3, Pages 315-323Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(03)00063-1
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Funding
- NINDS NIH HHS [R01 NS040296, R01 NS040296-02] Funding Source: Medline
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After much debate, recent progress indicates that the synaptic vesicle protein synaptotagmin I probably functions as the calcium sensor for synchronous neurotransmitter release. Following calcium influx into presynaptic terminals, synaptotagmin I rapidly triggers the fusion of synaptic vesicles with the plasma membrane and underlies the fourth-order calcium cooperativity of release. Biochemical and genetic studies suggest that lipid and SNARE interactions underlie synaptotagmin's ability to mediate the incredible speed of vesicle fusion that is the hallmark of fast synaptic transmission.
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