Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 7, Issue 3, Pages 411-425Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.7.3.411
Keywords
autoimmunity; IL-1R; jun n-terminal kinase (JNK); NF-kappa B; septic shock; toll-like receptor (TLR); TNF-R; TNF-receptor-associated factor (TRAF)
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TNF-receptor-associated factors (TRAFs) are the bottleneck of the TNF-receptor (TNF-R) family signal transduction. They integrate the signalling from many members of the TNF-R family and initiate intracellular signalling cascades aimed at the activation of NF-kappaB and c-jun, the reprogramming of gene expression and the control of cell death. Deregulation of these pathways is the cause of several autoimmune and inflammatory diseases. The specificity and interaction of the members of the TRAF family with the TNF-R entails the recognition of just a 4 - 6 amino acid motif in the cytosolic region of the receptor, suitable as an attractive target for drug discovery. This review summarises the current knowledge on TRAFs and discusses the pros and cons of their application as targets for drug discovery.
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