Journal
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 33, Issue 6, Pages 595-599Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0965-1748(03)00038-9
Keywords
Dermacentor; Rdl; GABA
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The American dog tick Dermacentor variabilis is a major transmitter of bacterial and viral pathogens in human and animal populations, and compounds active against this species would benefit both human and animal health. Invertebrate GABA-gated chloride channels are validated targets of commonly used insecticides and acaricides. We cloned a novel member of the invertebrate GABA-gated chloride channel gene family from Dermacentor variabilis, Rdl(Dv). The closest homologue of the predicted gene product of Rdl(Dv) is the RDL protein encoded by the GABA-gated chloride channel gene Drosophila Rdl (Resistance to Dieldrin), with which it shares 64% amino acid identity. When expressed in Xenopus oocytes, Rdl(Dv) produces GABA-activated currents blocked by the known insecticides and RDL antagonists fipronil and picrotoxinin. These results suggest that Rdl(Dv) encodes a GABA-gated chloride channel subunit, making it a potential target for compounds active against the tick D. variabilis. (C) 2003 Elsevier Science Ltd. All rights reserved.
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