Journal
IMMUNITY
Volume 18, Issue 6, Pages 837-848Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(03)00149-3
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Funding
- NIAID NIH HHS [AI-31451, T32 AI-07512] Funding Source: Medline
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We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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