Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2003, Issue 11, Pages 2021-2034Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200200518
Keywords
bioorganic chemistry; ceramide; cell surface engineering; glycolipids; sphingolipids
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Ceramide is the hydrophobic membrane anchor of glycosphingolipids, a vital component of the human skin, and a novel signaling substance. We give an overview of ceramide analogues that have been prepared to address biochemical questions related to the various functions of this lipid. We also discuss possible therapeutic applications. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
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