4.5 Article

A novel estrogen receptor ligand template

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 13, Issue 11, Pages 1919-1922

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00307-X

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Three synthetic routes towards a novel estrogen receptor ligand template based on a rigid bicyclo-[3.3.1]-nonene core have been investigated. The prototype compound exhibits potent binding at the ERbeta receptor and promising estrogen receptor subtype selectivity. (C) 2003 Elsevier Science Ltd. All rights reserved.

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