Journal
VACCINE
Volume 21, Issue 19-20, Pages 2607-2615Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00100-2
Keywords
hepatitis E; vaccine; monkey
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Funding
- NIAID NIH HHS [AI-0035] Funding Source: Medline
- PHS HHS [N01-A0-02733] Funding Source: Medline
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We have demonstrated that recombinant hepatitis E vaccine suitable for clinical evaluation was highly immunogenic and efficacious in preventing hepatitis E and even infection in rhesus macaques following intravenous challenge with three different genotypes of hepatitis E virus (HEV). Two doses of vaccine were essential for optimal protection; the two-dose regimen was more important than the formulation of the vaccine for achieving efficacy. The titers of anti-HEV that were protective in this study were quantified against a World Health Organization (WHO) standard. This permits direct comparison of the results with other studies. The results of this pre-clinical trial of a candidate hepatitis E vaccine strongly suggest that it will be highly efficacious for preventing hepatitis E in the field trial of this vaccine that is currently in progress in Nepal. (C) 2003 Elsevier Science Ltd. All rights reserved.
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