Journal
TETRAHEDRON LETTERS
Volume 44, Issue 23, Pages 4369-4371Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00941-9
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A variety of fused 3-aminoimidazoles have been synthesised by a microwave assisted Ugi three-component Coupling (3cc) reaction catalysed by scandium triflate in methanol as solvent. Yields of 33-93% have been achieved after just 10 mill of microwave irradiation using a simple one-stage procedure. The methodology described is suitable for the rapid and efficient synthesis of a range of fused heterocycles of pharmacological interest. (C) 2003 Elsevier Science Ltd. All rights reserved.
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