Journal
EMBO JOURNAL
Volume 22, Issue 11, Pages 2546-2551Publisher
WILEY
DOI: 10.1093/emboj/cdg261
Keywords
adaptive immune response; dendritic cells; innate immune response; interleukin 2; regulatory T cells
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Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes.
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