Journal
FEBS LETTERS
Volume 544, Issue 1-3, Pages 74-78Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)00476-9
Keywords
pre-B-cell colony-enhancing factor; cell cycle; subcellular distribution; cell nucleus
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A cDNA encoding the homolog of the human pre-B-cell colony-enhancing factor (PBEF), a cytokine-like secreted protein, was isolated from a rat cDNA library. This protein existed in both the cytoplasm and nucleus of the cells, and the amount was higher in the cytoplasm than in the nucleus of proliferating PC-12 and Swiss 3T3 cells but higher in the nucleus than in the cytoplasm of the PC-12 cells treated with nerve growth factor and the 3T3 cells grown to a confluent state. Thus, the so-called PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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