Journal
CANCER LETTERS
Volume 195, Issue 2, Pages 235-241Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00108-8
Keywords
angiogenesis; apoptosis; cyclooxygenase-2
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The aim of the present study is to investigate the relation of cyclooxygenase (COX)-2 with liver metastasis. Pieces of human colon cancer xenograft were implanted orthotopically (CI), as well as intraperitoneally, and subcutaneously. Liver metastasis developed most frequently, and the COX-2 expression of both mRNA and protein of the tumors was the most dominant in the CI group. In contrast, the expression of COX-1 or vascular endothelial cell growth factor mRNAs had no significant differences among the groups. The intensity of COX-2 mRNA was negatively correlated with the apoptotic index. In conclusion, COX-2 plays an important role in organ-specific metastasis of the colon cancer. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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