Journal
FEBS LETTERS
Volume 545, Issue 1, Pages 61-70Publisher
WILEY
DOI: 10.1016/S0014-5793(03)00394-6
Keywords
ATP synthase; subunit rotation; ATP synthesis; ATP hydrolysis; molecular motor; proton transport
Funding
- NIGMS NIH HHS [GM25349] Funding Source: Medline
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Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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