Journal
NEUROSCIENCE LETTERS
Volume 343, Issue 3, Pages 185-189Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00383-5
Keywords
ATP-sensitive potassium channels; primary afferent neurons; pinacidil; diazoxide; glibenclamide; neuropathy; chronic constriction injury; gabapentin
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Funding
- NINDS NIH HHS [NS R01-42150] Funding Source: Medline
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ATP-sensitive potassium (K-ATP) currents were examined in dorsal root ganglion neurons from neuropathic and control rats using whole-cell voltage clamp recordings. K-ATP channel openers (diazoxide and pinacidil) enhanced, and the blocker glibenclamide inhibited an outward current in control neurons in a manner dependent on the pipette ATP concentration. Analysis of reversal potentials showed that this current is carried by K+ ions. Outward current in cells from rats with peripheral nerve injury was not sensitive to modulators of K-ATP channels. Gabapentin, a putative K-ATP channel opener, had minimal effect on currents in either group of neurons. We conclude that normal primary afferent neurons express K-ATP channels that conduct current which is eliminated by peripheral nerve injury. Gabapentin does not affect this current significantly. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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