Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 278, Issue 24, Pages 21510-21516Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M212764200
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c-Jun is a member of the AP- 1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of c- Jun function as a transactivator with respect to members of the basal transcription machinery, TATA- binding protein-associated factors ( TAFs). We show that one member of the family, human TAF7 ( formerly TAF(II)55), physically interacts with c- Jun through two independent interaction domains, within the N- and C- terminal part of c-Jun. Interaction in vitro correlates with enhanced transactivation function of c- Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7. TAF7 interacts preferentially with DNA- bound phosphorylated c- Jun, suggesting that TAF7 represents a novel c- Jun co- activator mediating activation of AP- 1 target genes in response to extracellular signals.
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