Journal
CELL
Volume 113, Issue 6, Pages 789-801Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(03)00427-6
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Funding
- NIGMS NIH HHS [R01 GM53827, R01 GM061576, R01 GM61576, P50 GM62529, R01 GM55440, P01 GM64676, R37 GM29169, R01 GM54762] Funding Source: Medline
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Cryo-EM density maps showing the 70S ribosome of E. coli in two different functional states related by a ratchet-like motion were analyzed using real-space refinement. Comparison of the two resulting atomic models shows that the ribosome changes from a compact structure to a looser one, coupled with the rearrangement of many of the proteins. Furthermore, in contrast to the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo large conformational changes following the ratchet-like motion, suggesting an important role of ribosomal proteins in facilitating the dynamics of translation.
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