Journal
DEVELOPMENTAL BIOLOGY
Volume 258, Issue 2, Pages 406-418Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0012-1606(03)00123-4
Keywords
Wnt signaling; beta-catenin; neural stem cells; neuronal progenitors; progenitor pool; proliferation versus differentiation
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beta-Catenin is an essential component of the canonical Wnt signaling system that controls decisive steps in development. We employed here two conditional beta-catenin mutant alleles to alter beta-catenin signaling in the central nervous system of mice: one allele to ablate beta-catenin and the second allele to express a constitutively active beta-catenin. The tissue mass of the spinal cord and brain is reduced after ablation of beta-catenin, and the neuronal precursor population is not maintained. In contrast, the spinal cord and brain of mice that express activated beta-catenin is much enlarged in mass, and the neuronal precursor population is increased in size. P-Catenin signals are thus essential for the maintenance of proliferation of neuronal progenitors, controlling the size of the progenitor pool, and impinging on the decision of neuronal progenitors to proliferate or to differentiate. (C) 2003 Elsevier Science (USA). All rights reserved.
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