Journal
JOURNAL OF IMMUNOLOGY
Volume 170, Issue 12, Pages 6151-6157Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.12.6151
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Funding
- NHLBI NIH HHS [HL66941, HL69464, HL57505] Funding Source: Medline
- NIAID NIH HHS [AI46637, AI40305] Funding Source: Medline
- NIAMS NIH HHS [AR47360] Funding Source: Medline
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Abs specific for phosphorylcholine (PC) are known to contribute to the immune defense against a variety of microbial infections. To assess for other types of binding interactions, we performed surveys of anti-PC Abs of diverse biologic origins and structural diversity and demonstrated a common autoreactivity for oxidatively modified low density lipoprotein and other oxidation-specific structures containing PC-Ags. We also found that cells undergoing apoptosis sequentially express a range of oxidation-specific neo-self PC determinants. Whereas natural Abs to PC recognized cells at early stages of apoptosis, by contrast, an IgG anti-PC Ab, representative of a T cell-dependent response, recognized PC determinants primarily associated with late stages of apoptosis. Cumulatively, these results demonstrate a fundamental paradigm in which Abs from both the innate and the T cell-dependent tiers of the B cell compartment recognize a minimal molecular motif arrayed both on microbes and as neo-self Ags linked to atherosclerosis and autoimmune disease.
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