Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 13, Issue 12, Pages 2065-2069Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00319-6
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- NIGMS NIH HHS [R01GM61587] Funding Source: Medline
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The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 mumol versus T. cruzi and five gave similar values versus L. donovani. (C) 2003 Elsevier Science Ltd. All rights reserved.
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