Journal
NEURON
Volume 38, Issue 6, Pages 929-939Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(03)00322-2
Keywords
-
Categories
Funding
- NIDA NIH HHS [R01 DA10266] Funding Source: Medline
Ask authors/readers for more resources
Action potential-independent transmitter release is random and produces small depolarizations in the postsynaptic neuron. This process is, therefore, not thought to play a significant role in impulse propagation across synapses. Here we show that calcium flux through presynaptic neuronal nicotinic receptors leads to mobilization of store calcium by calcium-induced calcium release. Recruitment of store calcium induces vesicular release of glutamate in a manner consistent with synchronization across multiple active zones in the CA3 region of the rat hippocampus. This modulation of action potential-independent release of glutamate is sufficient to drive the postsynaptic pyramidal cell above its firing threshold, thus providing a mechanism for impulse propagation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available