A convenient preparation of dityrosine via Miyaura borylation-Suzuki coupling of iodotyrosine derivatives

Dityrosine has been prepared from 3-iodo-L-tyrosine derivatives by sequential Miyaura borylation and Suzuki coupling reactions. A tandem borylation-coupling protocol results in improved yields of the dityrosine derivatives. Suitable protecting group strategies are employed to allow for global deprotection as the final step. (C) 2003 Elsevier Science Ltd. All rights reserved.