Journal
NUTRITION
Volume 19, Issue 7-8, Pages 676-680Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0899-9007(03)00072-8
Keywords
soybean protein; hydrolysate; casein; cholesterol; rat; lipid metabolism; undialyzed soybean protein fraction; hypercholesterolemia; rats
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OBJECTIVE: We investigated lipid metabolism in hypercholesterolemic rats after replacing casein with different amounts of undialyzed soybean protein fraction. METHODS: The hypercholesterolemic rats were fed cholesterol-free diets containing 2%, 5%, or 10% undialyzed soybean protein fraction (UDSP) for 4 wk. RESULTS: The 5% and 10% UDSP groups had significantly lower plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol concentrations than did the other groups (P < 0.05). In addition, significantly higher fecal total steroid excretion was observed in these two groups. However, the different amounts of UDSP did not influence liver lipid, plasma high-density lipoprotein cholesterol, body weight gain, daily food intake, or feeding efficiency. CONCLUSION: These results suggested a dose-dependent reduction in plasma cholesterol when casein was replaced stepwise with UDSP (5% or 10%) as a protein source. The hypocholesterolemic effect might have been due to an increase in total fecal steroid excretion.
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