Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 7, Pages 939-942Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np020503d
Keywords
-
Funding
- NCI NIH HHS [R01 CA47135, CA-52955] Funding Source: Medline
Ask authors/readers for more resources
A Fijian collection of the calcareous sponge Leucetta sp. was investigated and yielded four new imidazole alkaloids. One compound, (+)-calcaridine A (6), is unique in its overall structure and consists of a geminally substituted 2-aminoimidazolidinone. An additional compound, (-)-spirocalcaridine A (7), is distinctive in its hexahydrocyclopentamidazol-2-ylidenamine spiro-linked to a cyclohexenone. A third compound, (-)-spirocalcaridine B (8), is the OCH3 analogue of 7. These compounds have unprecedented skeletons and functionality and are the first nonorganometalic chiral aminoimidazoles isolated from calcareous sponges. The two issues discussed here include the challenges associated with the structure elucidations of 6 and 7 and the relationships to previously encountered Leucetta metabolites.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available