Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 92, Issue 7, Pages 1407-1418Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.10411
Keywords
hydrotalcite; intercalation compound; poorly water-soluble drug; solubility
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A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH < 4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin. (C) 2003 Wiley-Liss, Inc.
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