Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 3, Issue 7, Pages 1019-1026Publisher
ELSEVIER
DOI: 10.1016/S1567-5769(03)00100-0
Keywords
dopamine; T lymphocytes; signal transduction; cytokines
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The effect of dopamine (DA) on the release of cytokines from activated human T cells has been evaluated to analyze the mechanism by which physiological concentration of dopamine inhibits T cell proliferation. Dopamine inhibited anti-CD3 mAb-induced release of both Th1 and Th2 cytokines, IL2, IFN-gamma and IL4 from T cells by specific class of dopamine receptors. This action of dopamine was mediated by a new mechanism. Dopamine suppressed non-receptor tyrosine kinases, Lck and Fyn expression which are the initial and pivotal signaling steps in T cell receptor (TCR) mediated different down stream signaling cascades, leading to cytokine release and subsequent clonal expansion of these immune effector cells. (C) 2003 Elsevier Science B.V. All rights reserved.
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