Journal
BIOINFORMATICS
Volume 19, Issue -, Pages i118-i121Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btg1015
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Funding
- NHGRI NIH HHS [T32 HG0047, K22 HG00056] Funding Source: Medline
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We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003, Proc. Natl Acad. Sci. USA, 100, 189-192). Rather than being translated to yield protein, these transcripts are expected to be degraded and may be subject to regulated unproductive splicing and translation (RUST). Our initial experimental studies are consistent with these predictions and suggest an unappreciated role for NMD in several human diseases.
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