Journal
ENDOCRINOLOGY
Volume 144, Issue 7, Pages 2757-2760Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2003-0163
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Funding
- NCRR NIH HHS [RR 14451] Funding Source: Medline
- NINDS NIH HHS [NS 41725] Funding Source: Medline
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Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.
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