Related references
Note: Only part of the references are listed.Possible new LNK mutations in myeloproliferative neoplasms
Jung-Sook Ha et al.
AMERICAN JOURNAL OF HEMATOLOGY (2011)
Adapter Protein SH2B1β Binds Filamin A to Regulate Prolactin-Dependent Cytoskeletal Reorganization and Cell Motility
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MOLECULAR ENDOCRINOLOGY (2011)
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PLOS ONE (2011)
The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients
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PEDIATRIC DIABETES (2011)
Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection
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AMERICAN JOURNAL OF HUMAN GENETICS (2010)
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
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BLOOD (2010)
Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms
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BLOOD (2010)
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
A. Alcina et al.
GENES AND IMMUNITY (2010)
Lnk constrains myeloproliferative diseases in mice
Alexey Bersenev et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Lnk regulates integrin alpha IIb beta 3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
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JOURNAL OF CLINICAL INVESTIGATION (2010)
Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing
Tomoyuki Matsumoto et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Adaptor protein Lnk inhibits c-Fms-mediated macrophage function
Saskia Gueller et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2010)
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
A. Pardanani et al.
LEUKEMIA (2010)
Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
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LNK Mutations in JAK2 Mutation-Negative Erythrocytosis.
Terra L. Lasho et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo
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PLOS GENETICS (2010)
Pivotal Role of Lnk Adaptor Protein in Endothelial Progenitor Cell Biology for Vascular Regeneration
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CIRCULATION RESEARCH (2009)
Expression of the adaptor protein Lnk in leukemia cells
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EXPERIMENTAL HEMATOLOGY (2009)
MAPK signaling pathways in the regulation of hematopoiesis
Christian R. Geest et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2009)
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
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JOURNAL OF LEUKOCYTE BIOLOGY (2009)
Adapter Protein SH2B1β Cross-Links Actin Filaments and Regulates Actin Cytoskeleton
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MOLECULAR ENDOCRINOLOGY (2009)
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
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NATURE GENETICS (2009)
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Daniel F. Gudbjartsson et al.
NATURE GENETICS (2009)
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Nicole Soranzo et al.
NATURE GENETICS (2009)
The Drosophila SH2B Family Adaptor Lnk Acts in Parallel to Chico in the Insulin Signaling Pathway
Christian Werz et al.
PLOS GENETICS (2009)
Adaptor protein Lnk associates with Tyr568 in c-Kit
Saskia Gueller et al.
BIOCHEMICAL JOURNAL (2008)
Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells
David G. Kent et al.
BLOOD (2008)
Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells
Clotilde Simon et al.
BLOOD (2008)
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals
Hitoshi Takizawa et al.
EXPERIMENTAL HEMATOLOGY (2008)
Newly identified genetic risk variants for celiac disease related to the immune response
Karen A. Hunt et al.
NATURE GENETICS (2008)
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
Sigal Gery et al.
BLOOD (2007)
Identification of SH2B2β as an inhibitor for SH2B1- and SH2B2α-promoted janus kinase-2 activation and insulin signaling
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ENDOCRINOLOGY (2007)
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Jun Seita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mechanisms of disease: The myeloproliferative disorders
Peter J. Campbell et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Pathophysiology defined by altered signal transduction pathways
Andrew E. Schade et al.
CELL CYCLE (2006)
TNF-α induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells
Meifang Wan et al.
JOURNAL OF SURGICAL RESEARCH (2006)
Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state
Jason H. Kurzer et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS
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JOURNAL OF MOLECULAR BIOLOGY (2006)
The role of Janus kinases in haemopoiesis and haematological malignancy
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BRITISH JOURNAL OF HAEMATOLOGY (2006)
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
Natalija Buza-Vidas et al.
GENES & DEVELOPMENT (2006)
The adaptor molecule Lnk negatively regulates tumor necrosis factor-α-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways
Juliette Fitau et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk
H Takizawa et al.
BLOOD (2006)
The interaction between the adaptor protein APS and Enigma is involved in actin organisation
R Barrés et al.
EXPERIMENTAL CELL RESEARCH (2005)
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
DC Ren et al.
CELL METABOLISM (2005)
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
W Tong et al.
BLOOD (2005)
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and lnk-deficient mice
H Ema et al.
DEVELOPMENTAL CELL (2005)
APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation
M Iseki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Kinase activation through dimerization by human SH2-B
M Nishi et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-Bβ
JH Kurzer et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions:: APS-deficiency causes augmented degranulation and reduced actin assembly
C Kubo-Akashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains
M Iseki et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
A phenylalanine zipper mediates APS dimerization
D Dhe-Sirano et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
W Tong et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
CJ Duan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling
MY Ahn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor
JJ Hu et al.
MOLECULAR CELL (2003)
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
Y Gu et al.
SCIENCE (2003)
Autoinhibition of the Kit receptor tyrosine kinase by the cytosolic juxtamembrane region
PM Chang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit
P Wollberg et al.
BIOCHEMICAL JOURNAL (2003)
Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein
S Takaki et al.
JOURNAL OF IMMUNOLOGY (2003)
Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein
I Nobuhisa et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells
G Boulday et al.
TRANSPLANTATION (2002)
Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity
N Yabana et al.
ONCOGENE (2002)
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
L Velazquez et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
SH2-B is required for both male and female reproduction
S Ohtsuka et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
SH2-Bβ is a Rac-binding protein that regulates cell motility
M Diakonova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Enhanced Hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
S Takaki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration
DA Calderwood et al.
NATURE CELL BIOLOGY (2001)
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis
N Yousaf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Control of B cell production by the adaptor protein Lnk: Definition of a conserved family of signal-modulating proteins
S Takaki et al.
IMMUNITY (2000)
Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein
XQ He et al.
MOLECULAR IMMUNOLOGY (2000)
Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation
YJ Li et al.
JOURNAL OF IMMUNOLOGY (2000)
Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-Bβ
LY Rui et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
SH2-B is required for growth hormone-induced actin reorganization
J Herrington et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
RA Ortmann et al.
ARTHRITIS RESEARCH (2000)