Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 58, Issue 4, Pages 287-294Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00005-010-0083-0
Keywords
Inflammation; Allergy; Toll-like receptors; Hypoxia; HIF-1
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Funding
- Royal Society [RG080474]
- Medway School of Pharmacy, University of Kent
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Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability. In the last years there has been increasing evidence about the role of this factor in inflammatory/innate immune reactions. It has also been found to contribute to different types of allergic inflammation. In this review the current knowledge about the accumulation and role of HIF-1 in Toll-like receptor-mediated and allergic inflammation is summarized. Differential biochemical mechanisms employed to stabilize the protein in different cases are discussed.
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