Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 57, Issue 4, Pages 269-278Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00005-009-0037-6
Keywords
complement; stem cell mobilization; CXCR4; SDF-1
Categories
Funding
- NIH [R01 CA106281, R01 DK074720]
- Stella and Henry Endowment
- Ministry of Science and Higher Education [N 401024536]
Ask authors/readers for more resources
The mobilization of hematopoietic stem/progenitor cells (HSPCs) from bone marrow into peripheral blood (PB) is still not fully understood. Different chemokines, cytokines, growth factors, and neurotransmitters have been described that facilitate this process. However, mounting evidence suggests that mobilization of HSPCs is a part of the immune response and is mediated by innate immunity. We discuss evidence showing that complement system cleavage fragments play a crucial role in both the retention and mobilization of HSPCs by modulating their responsiveness to stromal-derived growth factor-1 (SDF-1) gradient (by C3-derived anaphylatoxins) and by modulating the release of granulocytes into PB that subsequently facilitate the egress of HSPCs (by C5-derived anaphylatoxins).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available