Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 42, Issue 1, Pages 113-117Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00005344-200307000-00017
Keywords
acquired QT syndrome; sodium channel; torsades de pointes
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DPI 201-106 delays sodium channel inactivation. Acute administration of DPI 201-106 prolonged the QT interval, provoked spontaneous torsades de pointes in one patient, and facilitated stimulation-induced polymorphic ventricular tachyarrhythmias in two patients. Similar to the observations in animal studies, delaying sodium channel inactivation is a new form of the acquired long QT syndrome, mimicking long QT syndrome type 3.
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