Journal
NATURE MEDICINE
Volume 9, Issue 7, Pages 831-835Publisher
NATURE RESEARCH
DOI: 10.1038/nm0703-831
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The use of bacteria and bacterial extracts for immunotherapy has a checkered past. Recent developments in immunology reveal that these nonspecific immune activators actually work by triggering specific receptors that are expressed by subsets of immune cells. Identification of these receptors and the molecular signaling pathways that they activate has enabled a new era of specific targeted immunotherapy using chemically synthesized mimics of pathogen molecules.
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