Novel prospective respiratory motion correction approach for free-breathing coronary MR angiography using a patient-adapted affine motion model

A novel technique is presented which enables the calibration of a 3D affine respiratory motion model to the individual motion pattern of the patient. The concept of multiple navigators and precursory navigators is introduced to address nonlinear properties and hysteresis effects of the model parameters with respect to the conventional diaphragmatic navigator. The optimal combination and weighting of the navigators is determined on the basis of a principal component analysis (PCA). Thus, based on a given navigator measurement the current motion state of the object can be predicted by means of the calibrated motion model. The 3D motion model is applied in high-resolution coronary MR angiography examinations (CMRA) to prospectively correct for respiration-induced motion. The basic feasibility of the proposed calibration procedure was shown in 16 volunteers. Furthermore, the application of the calibrated motion model for CMRA examinations of the right coronary artery (RCA) was tested in 10 volunteers. The superiority of a calibrated 313 translation model over the conventional 1 D translation model with a fixed correction factor and the potential of affine prospective motion correction for CMRA are demonstrated. (C) 2003 Wiley-Liss, Inc.