Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 8, Issue 3, Pages 472-478Publisher
SPIE-INT SOCIETY OPTICAL ENGINEERING
DOI: 10.1117/1.1578643
Keywords
metal-enhanced fluorescence; idocyanine green; silver islands
Funding
- NCI NIH HHS [CA-100982] Funding Source: Medline
- NCRR NIH HHS [P41 RR008119, RR-08119] Funding Source: Medline
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Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging. (C) 2003 Society of Photo-Optical Instrumentation Engineers.
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