Journal
JOURNAL OF IMMUNOLOGY
Volume 171, Issue 1, Pages 27-31Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.171.1.27
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- NIAID NIH HHS [AI00348, AI44644] Funding Source: Medline
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In this study, we examined the cytotoxic activity of effector and memory CD8 T cells in vivo. At the peak of the CTL response following an acute lymphocytic choriomeningitis virus infection, effector CD8 T cells exhibited extremely rapid killing and started to eliminate adoptively transferred target cells within 15 min by a perforin-dependent mechanism. Although resting memory CD8 T cells are poorly cytolytic by in vitro Cr-51 release assays, there was rapid elimination (within 1-4 h) of target cells after transfer into immune mice, and both CD62L(high) and CD62L(low) memory CD8 T cells were able to kill rapidly in vivo. Strikingly, when directly compared on a per cell basis, memory CD8 T cells were only slightly slower than effector cells in eliminating target cells. These data indicate that virus specific memory CD8 T cells can rapidly acquire cytotoxic function upon re-exposure to Ag and are much efficient killers in vivo than previously appreciated.
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