Residue formation of fumonisin B1 in porcine tissues

The residues derived from the uptake of fumonisin B1, a toxic metabolite of Fusarium verticillioides frequently occurring in corn and corn products, were determined in growing pigs. After oral administration of 100 mg FB1 /animal/day for 5-11 days, serum, bile, lung, liver, kidney, brain, spleen, pancreas, heart, muscle, eye, and fat samples were collected immediately and analysed by LC-MS. The highest values were measured in kidney (833 +/- 1329 mug kg(-1) , mean +/- SD), liver (231 +/- 163 mug kg(-1) ), lung (170 +/- 311 mug kg(-1) ) and spleen (854 +/- 2212 mug kg(-1) ). Muscle contained 26 +/- 41 mug kg(-1) , while in fat only 2 +/- 3 mug kg(-1) were traceable. Despite the potential accumulation over extended feeding periods as well as the large variations in the residue formation of FB1 , a carry-over in edible tissues from swine was considered not to be of toxicological relevance.